Ectodysplasin regulates the lymphotoxin- pathway for hair differentiation
نویسندگان
چکیده
*Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224; †Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, and Basic Research Program, SAIC–Frederick, Inc., Frederick, MD 21702; and ‡Laboratory of Molecular Immunology, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia
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The ectodysplasin pathway in feather tract development.
The ectodysplasin pathway, comprising the ligand ectodysplasin, its receptor Edar and a dedicated death domain adaptor protein Edaradd, plays an important role in epidermal organ formation in mammals. Mutations in the genes encoding these proteins cause dysplasia or absence of teeth, sweat glands and hair follicles. However, the relative position of this pathway in the regulatory hierarchy dire...
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The developing submandibular salivary gland (SMG) is a well-studied model for tissue interactions and branching morphogenesis. Its development shares similar features with other ectodermal appendages such as hair and tooth. The ectodysplasin (Eda) pathway is essential for the formation and function of several ectodermal organs. Mutations in the signaling components of the Eda pathway lead to a ...
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Lymphotoxin-beta (LTbeta) is a key regulator of immune system development, but also affects late stages in hair development. In addition, high expression of LTbeta at an early stage in epidermis hinted at a further function in hair follicle induction or epithelial development. We report that hair follicles were normally induced in LTbeta(-/-) skin, but the periderm detached from the epidermis e...
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